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Could a Common Probiotic Help Lower Esophageal Cancer Risk?

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Mendelian randomization study of the role of TD CD4+ T cells in the association between Streptococcus thermophilus and esophageal cancer.DOI 10.1097MD.0000000000047174

Esophageal cancer is a serious disease that affects the tube connecting your mouth to your stomach.

Scientists are learning that the bacteria living in our gut—known as the microbiome—might play a role in how this cancer develops.

This study looked at a type of helpful bacteria called Streptococcus thermophilus, which is often found in yogurt and probiotics. Using genetic research methods, scientists found that people with higher natural levels of this bacteria had a lower risk of developing esophageal cancer.The study also found that part of this protective effect may be due to the immune system—specifically, a type of white blood cell called CD4+ T cells.These cells help control how the body fights off infections and diseases, including cancer.

While the bacteria didn’t explain everything, it did seem to make a meaningful difference. This points to a new idea: strengthening the right gut bacteria might help protect against cancer by supporting the immune system.More research is needed, but the findings open the door to future treatments or even prevention strategies using probiotics. In the meantime, eating foods that support a healthy gut—like yogurt with live cultures—could be one small way to care for your overall health.

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Dr Harsh Shah - GI & HPB Oncosurgeon in Ahmeadbad
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