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GERD and Pancreatic Cancer: Can the Fats in Your Diet Make a Difference?

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The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk DOI 10.1186s12876-025-04445-2

People with gastroesophageal reflux disease (GERD) often deal with heartburn or stomach acid coming up into the throat. This new study found that GERD may do more than just cause discomfort. It may raise the risk of pancreatic cancer.

Pancreatic cancer is one of the deadliest cancers. It’s hard to find early and hard to treat. This study shows that people with GERD may be more likely to get pancreatic cancer. The study also looked at certain fats in the diet and found they may play a small role in this risk.

There are two main kinds of polyunsaturated fats in the body: omega-6 and omega-3. Most people eat more omega-6 and not enough omega-3. The study found that GERD increases the levels of omega-6 compared to omega-3. This higher ratio may increase the risk of pancreatic cancer.

The researchers believe that keeping this fat balance in check might help lower the risk. They say people with GERD should speak to their doctor about screening and treatment. They also suggest eating more omega-3 fats. These are found in fatty fish like salmon, walnuts, and flaxseeds. Reducing foods high in omega-6, like processed snacks and some vegetable oils, may also help.

This is early research, but it gives hope. A few small changes in diet could help people with GERD protect their health.

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Dr Harsh Shah - GI & HPB Oncosurgeon in Ahmeadbad
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