A study analyzed 814 patients who had colorectal adenomas with high-grade dysplasia (HGD) removed, revealing significant risks of advanced neoplasia (AN) and colorectal cancer (CRC). Over 2000 person-years of follow-up showed AN and CRC incidence densities of 44.3 and 4.4 per 1000 person-years, respectively. Synchronous polyps and elevated baseline carcinoembryonic antigen (CEA) levels were key risk factors. However, surveillance colonoscopies markedly reduced AN and CRC incidences. Patients with these risk factors need frequent monitoring to manage their long-term cancer risks effectively. Full study available at: https://doi.org/10.1007/s00464-024-10898-5
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