Early-onset colorectal cancer (EOCRC) presents most commonly with hematochezia (45%) and abdominal pain (40%). A systematic review and meta-analysis revealed that these symptoms are associated with a significantly increased risk of EOCRC, with hematochezia showing a 5- to 54-fold increase in risk. Despite this, delays in diagnosis are common, averaging 4 to 6 months from symptom onset. These findings emphasize the need for GPs to maintain a high index of suspicion for EOCRC in younger patients presenting with these symptoms. Prompt diagnostic workup, including colonoscopy, should be considered to reduce delays and improve outcomes.
Key Points:
Hematochezia and abdominal pain are critical red flags.
Average diagnostic delay: 4 to 6 months.
Importance of timely diagnostic workup for EOCRC.
For more details, refer to the full article: DOI: 10.1001/jamanetworkopen.2024.13157
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